The Oxytocin-Oxytocin Receptor System and Its Antagonists as Tocolytic Agents
نویسندگان
چکیده
منابع مشابه
The Oxytocin-Oxytocin Receptor System and Its Antagonists as Tocolytic Agents
Oxytocin, a hormone involved in numerous physiologic processes, plays a central role in the mechanisms of parturition and lactation. It acts through its receptor, which belongs to the G-protein-coupled receptor superfamily, while Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) is the main pathway via which it exerts its action in the myometrium. Changes in receptor levels, receptor...
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OBJECTIVES Oxytocin (OXY) in addition to peripheral actions has many central regulatory functions which can be studied on animal models. In the present study we examined in rats, which behavioral actions of OXY and long-acting carba-analog of OXY carbetocin (CBT) in the open-field can be inhibited by OXY-receptor antagonists. Our interest focused on the behavioral patterns considered indicative...
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ژورنال
عنوان ژورنال: International Journal of Endocrinology
سال: 2011
ISSN: 1687-8337,1687-8345
DOI: 10.1155/2011/350546